Rejuran Healer Effects & Procedure Information: From How It Works to Recovery Care

Rejuran Healer is one of the skin booster procedures widely known even to those who have only heard the name in passing. It involves directly injecting polynucleotide (PN) ingredients—extracted and purified from salmon (or trout) DNA—into the dermis, and is introduced as a procedure that can be expected to help improve both skin texture and elasticity.

However, the effects and the degree to which they are felt may vary depending on individual skin condition, treatment area, and number of sessions. This article covers how Rejuran Healer works, the changes it is expected to bring, the procedure process and downtime, and home care during the recovery period after treatment.

How Rejuran Healer Works

The PN ingredient used in Rejuran Healer is a DNA-derived biopolymer that has been studied in various research contexts for tissue remodeling and cosmetic improvement purposes. Preclinical data have suggested mechanisms such as adenosine A2A receptor activation, angiogenesis, fibroblast proliferation, and extracellular matrix remodeling.

However, most related human studies have been reported at the level of small-scale trials or observational cohorts, so it is more accurate to understand this as "the possibility of inducing the restructuring or generation of matrix components such as collagen" rather than as "skin restructuring" outright. Since formulations, evaluation metrics, and follow-up periods differ across studies, there are still limitations in generalizing the results.

Changes That Can Be Expected from Rejuran Healer

Rejuran Healer is a procedure that aims to help with the following changes. Please note that the effects and the degree to which they are felt vary by individual.

Commonly mentioned changes include helping improve the environment for skin restructuring, helping refine skin texture, helping improve elasticity, and helping improve moisture retention.

A related research review also reported that polynucleotide injections showed promising results in terms of wrinkle reduction, skin texture improvement, and elasticity enhancement, though it was noted that the included studies were of low to moderate quality. Some observational studies focused on the eye area reported significant improvements in fine line assessment scores, but since these studies involved combined use with other products, the results cannot be attributed solely to Rejuran.

Procedure Process and Treatment Information Summary

The procedure generally proceeds in the following order: consultation and skin condition assessment, cleansing, application of topical anesthetic cream, injection of active ingredients into the dermis, and post-procedure soothing care. Since little to no dedicated recovery period is typically needed, returning to daily activities is described as relatively easy.

The procedure takes about 20–30 minutes depending on the treatment area, and topical anesthetic cream is generally used to reduce pain, though the degree felt varies by individual. Effects are generally described as gradually appearing from around 1–2 weeks after treatment, and the duration can vary depending on the product, area, and individual characteristics. It is often mentioned that initial treatments are done multiple times at 2–4 week intervals followed by maintenance sessions afterward, though it should be noted that this is not a standardized academic protocol but rather a schedule commonly recommended across various clinics.

Downtime and Precautions

Immediately after the procedure, minor embossed marks or small papules may appear at the injection sites, and temporary redness may accompany them. These marks or redness are generally described as subsiding within about 3–4 days, though this can vary by individual.

Side effects are generally reported to be mild and temporary, but it is important to thoroughly discuss individual skin condition and medical history with a medical professional before the procedure. Whether to undergo the procedure, the method, and the frequency should be determined through consultation.

Home Care During the Recovery Period After Treatment

Since the skin may become sensitive for a few days immediately after the procedure, avoiding harsh exfoliating products or high-concentration acid ingredients and maintaining a simple routine focused on cleansing and moisturizing may help with recovery.

In particular, during the period when minor marks or redness remain at the injection sites, care that protects and soothes the skin barrier should take priority, and once recovery has progressed to some degree, it is understood as a natural progression to move on to care that replenishes deep moisture.

Post-Procedure Recovery Is Shaped by Home Care

One approach is to divide home care into stages that align with this immediate post-procedure to recovery-period flow. The Aveju cream is designed as a 2-STEP system, where STEP1 Ultra Cera-Rich can be considered for use on skin that has become sensitive right after the procedure, for the purpose of soothing redness and caring for the skin barrier, while STEP2 Hydro Re-Boosting can be considered during the recovery period once redness has subsided, for the purpose of deep moisture care. However, this does not replace or guarantee the effects of the procedure itself, and regardless of product use, consulting a medical professional about the progress of the procedure and any adverse reactions should always take priority.

Medically reviewed by 아비쥬의원 의료진. (September 10, 2026)