Renewfill Effects and Treatment Information: From Principles to Recovery

Renewfill is known as a combination skin booster treatment that adds salmon-derived polynucleotides (PN) and a small amount of lidocaine to cross-linked sodium hyaluronate. It aims to help refine skin texture and improve elasticity and hydration by injecting active ingredients into the skin layers, and has drawn interest from those looking to try a low-commitment procedure due to its short treatment time and relatively brief recovery period.

However, the degree of noticeable effect and duration can vary from person to person depending on the treatment method and ingredient composition, so this article will walk through the principles, treatment process, effects and progression, and post-treatment home care in order.

What is the principle behind Renewfill?

Renewfill is introduced as a hybrid-type filler that combines highly elastic cross-linked HA with PN ingredients. The cross-linked HA is said to provide volume and longevity, while the added PN—described as a DNA fragment with a larger molecular fraction than the PDRN used in pharmaceuticals—is understood to play a supplementary role in helping improve the skin environment. However, this explanation of the mechanism is primarily based on materials provided by the relevant manufacturers, so some caution is warranted in interpretation.

The product is reported to contain a small amount of lidocaine to help reduce pain during injection. In actual treatments, a topical anesthetic cream is often used alongside it to further reduce discomfort.

In one open-label clinical trial (involving 15 adults with moderate or greater facial volume loss), the volume improvement trend confirmed by blinded evaluation at week 4 was reported to be maintained through week 24. The same study also reportedly observed decreased transepidermal water loss (TEWL), increased skin hydration, and a gradual improvement trend in elasticity measurements. However, this study has limitations as it was a small-scale open trial of only 15 participants without a randomized control group comparison, and the findings were disclosed in the form of a manufacturer press release, making it difficult to consider this as definitive evidence of efficacy.

The Renewfill Treatment Process and Duration

Typically, after a consultation and skin condition assessment, cleansing is performed, followed by application of a topical anesthetic cream to reduce pain. Active ingredients are then injected into the skin layers, followed by soothing care and post-treatment guidance, after which most people return to their daily routine without a specific recovery period.

Treatment time varies by area but is generally guided to take about 20-30 minutes. Pain levels vary by individual, but are known to be relatively mild due to the concurrent use of topical anesthesia.

Timing of Effects and Downtime

Effects are generally guided to become gradually noticeable starting 1-2 weeks after treatment, though the timing and degree of perception vary by individual. Duration can also vary depending on the product used, treatment area, and individual skin condition, so it is commonly recommended to undergo several sessions at 2-4 week intervals initially, followed by ongoing maintenance care.

Downtime is generally minimal, but faint injection marks or slight redness may remain for about 1-2 days. As is typical with HA-based treatments in general, reactions such as redness, swelling, tenderness, and bruising, if they occur, tend to improve within 1-2 weeks. However, this is not data specific to Renewfill but general information applicable to HA-based treatments overall, and may vary depending on the area, amount used, and individual differences.

Differences from Other Skin Boosters

Renewfill, Rejuran Healer, and Juvelook are all classified as skin boosters, but differ in their main ingredients and goals. Renewfill tends to focus on improving texture and elasticity by combining cross-linked HA with PN, Rejuran Healer is known as a product centered on salmon-derived PN, and Juvelook is introduced as using PDLLA together with HA to induce collagen production.

Which treatment is more suitable can vary depending on individual skin condition and concerns, so rather than making a simple comparison, it is advisable to choose through consultation with a specialist.

Post-Treatment Recovery and Home Care

While Renewfill tends to have relatively short downtime, minor irritation or temporary redness may remain immediately after treatment, so skin care during this period can affect subsequent condition. Sun protection, avoiding irritating ingredients, and thorough moisturizing care are particularly emphasized as important during this time.

A two-step approach can be helpful: focusing on soothing and barrier care with gentle ingredients for the sensitive skin immediately after treatment, then continuing with deep hydration care during the subsequent recovery period.

Home Care Determines Post-Treatment Recovery

Immediately after treatment, it's advisable to soothe the skin with low-irritation products that support barrier care. Abib Cream's STEP1 Ultra Cera-Rich is formulated to help soothe and support barrier care for skin that has become sensitive right after treatment, and continuing with STEP2 Hydro Re-boosting during the subsequent recovery period for deep hydration care is recommended. However, cosmetics do not replace the treatment itself, and if redness or irritation persists, consulting a specialist should be the priority.

Medically reviewed by 아비쥬의원 의료진. (September 10, 2026)